Gaps in some components’ abilities to measure cognitive performance may mean that their precision is limited.
Portions of one of the most commonly used tests to measure cognitive performance in Alzheimer’s disease trials may be too easy and may not accurately assess the range of patients’ cognitive abilities or detect their change over time, according to two complementary studies in the December 11, 2012, Alzheimer’s & Dementia.
Analyses of Alzheimer’s Disease Assessment Scale–Cognitive Behavior Section (ADAS-Cog) scores measured in 193 patients with mild disease who participated in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) in the course of two years detected limitations of the scale that could be improved, reported Jeremy Hobart, MD, PhD, of the Clinical Neurology Research Group, Peninsula College of Medicine and Dentistry, Plymouth, United Kingdom, and his colleagues.
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