BOSTON—Pregabalin reduced wake after sleep onset, compared with placebo and pramipexole, by 27.1 minutes and 26.9 minutes, respectively, according to research presented at the 26th Annual Meeting of the Associated Professional Sleep Societies. Pregabalin reduced the number of awakenings after sleep onset by 7.9, increased subjective total sleep time by 26.8 minutes, and increased slow-wave sleep by 32.1 minutes, compared with pramipexole.
Compared with placebo, pregabalin reduced patients’ International Restless Legs Scale (IRLS) score by six points, said Philip M. Becker, MD, Clinical Professor of Psychiatry at the University of Texas Southwestern Medical Center in Dallas. Compared with pramipexole, pregabalin reduced IRLS score by three points. Pregabalin also reduced periodic leg movements and arousals, compared with placebo and pramipexole. At baseline, patients taking pregabalin had 14 more leg movements per hour than patients taking pramipexole.
Pregabalin Versus Pramipexole and Placebo
Dr. Becker reported on pregabalin, pramipexole, and placebo in a randomized, double-blind, crossover study performed at 23 US sites. After a 10-day dose escalation period, equal numbers of patients took either 300 mg of pregabalin per day, 0.5 mg of pramipexole per day, or placebo for 19 days. Active treatment was followed by a taper and placebo washout period.