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May 2013 Volume 21 No. 5
Is Parkinson’s Disease a Prion Disorder?

AAN 2013 Meeting

Is Parkinson’s Disease a Prion Disorder?

SAN DIEGO—An increasing body of evidence suggests that Parkinson’s disease is a prion disorder, according to a review presented at the 65th Annual Meeting of the American Academy of Neurology. If the prion hypothesis is... More


BRAIN Initiative Seeks to Map the Human Brain

Feature Article

BRAIN Initiative Seeks to Map the Human Brain

President Obama is calling on neuroscientists inside and outside the federal government to join an ambitious effort to understand and map the activity of the human brain. If successful, this basic science work could lay the foundation for... More


One-Fifth of Neurologists May Not Know About the Risks of Antiepileptic Drugs

AAN 2013 Meeting

One-Fifth of Neurologists May Not Know About the Risks of Antiepileptic Drugs

SAN DIEGO—Approximately 20% of the members of the American Academy of Neurology (AAN) who take care of patients with epilepsy are not aware of the FDA’s major safety warnings about antiepileptic drugs (AEDs), according to... More


Monoclonal Antibody May Be Safe for Patients With Stroke

AAN 2013 Meeting

Monoclonal Antibody May Be Safe for Patients With Stroke

SAN DIEGO,—GSK 249320, an investigational drug intended to help repair brain injury, appears to be safe for patients with stroke, according to a phase I/II study presented at the 65th Annual Meeting of the American Academy... More


New Guideline Proposes Treatment for Neurocysticercosis

Feature Article

New Guideline Proposes Treatment for Neurocysticercosis

A new evidence-based guideline for adults and children with neurocysticercosis—tapeworm larvae seeded in the brain parenchyma—suggests that clinicians should consider treating patients with albendazole and either dexamethasone or... More


Beta-D-Glucan Test May Detect Fungal Meningitis

AAN 2013 Meeting

Beta-D-Glucan Test May Detect Fungal Meningitis

SAN DIEGO—Testing the CSF for beta-D-glucan may be an accurate method of detecting fungal meningitis, according to research reported at the 65th Annual Meeting of the American Academy of Neurology.


Beta-D-glucan... More


Childhood Migraine Tied to History of Infantile Colic

Feature Article

Childhood Migraine Tied to History of Infantile Colic

Children and adolescents who presented to the emergency department with migraine headache were six times more likely to have a history of colic during infancy than were those who presented for other reasons, according to a report in the... More


FDA’s Draft Guidance Targets Drug Development for Early Stages of Alzheimer’s Disease

Feature Article

FDA’s Draft Guidance Targets Drug Development for Early Stages of Alzheimer’s Disease

The FDA has issued a draft guidance designed to assist pharmaceutical companies in developing new drugs for patients who are in the early stages of Alzheimer’s disease. The proposed recommendations address patient selection and end points... More


Novel Exercise Program May Help Patients With Dementia

AAN 2013 Meeting

Novel Exercise Program May Help Patients With Dementia

SAN DIEGO—A novel exercise program focused on movements required to perform functions of daily living may improve cognitive function, physical performance, and caregiver burden for patients with mild to moderate dementia,... More


Is There a Ceiling Effect for the Accuracy of Stroke Diagnoses by EMS?

2013 International Stroke Conference

Is There a Ceiling Effect for the Accuracy of Stroke Diagnoses by EMS?

HONOLULU—Stroke diagnosis accuracy rates by emergency medical services increased from 71% to 77% during a three-year period in a community hospital setting after implementation of an education program, researchers reported... More


How Accurate Is EMS Identification of Stroke in an Urban Population?

2013 International Stroke Conference

How Accurate Is EMS Identification of Stroke in an Urban Population?

HONOLULU—Emergency medical services (EMS) in New York City have a positive predictive value of 64% for diagnosing stroke in an underserved minority population, with seizures being the leading confounder, according to... More


Pseudobulbar Affect May Influence Quality of Life for Patients With Stroke

2013 International Stroke Conference

Pseudobulbar Affect May Influence Quality of Life for Patients With Stroke

HONOLULU—More than one-third of patients with stroke may have pseudobulbar affect (PBA), according to research presented at the 2013 International Stroke Conference. Compared with patients with stroke, patients with stroke... More


Early Surgical Menopause Is Linked to Cognitive Decline

AAN 2013 Meeting

Early Surgical Menopause Is Linked to Cognitive Decline

SAN DIEGO—Earlier age at surgical menopause may be associated with a steeper decline in cognitive function and increased Alzheimer’s disease–related neuropathologic scores, according to two longitudinal studies presented... More


Tool May Help Identify Cognitive Deficits in Patients With Huntington’s Disease

AAN 2013 Meeting

Tool May Help Identify Cognitive Deficits in Patients With Huntington’s Disease

SAN DIEGO—The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) may help neurologists assess cognitive deficits in patients with Huntington’s disease, according to a study presented at the 65th... More


COMMENTARY by Alan M. Rapoport, MD—A Huge Risk Factor for Cardiovascular Disease

Commentary

COMMENTARY by Alan M. Rapoport, MD—A Huge Risk Factor for Cardiovascular Disease

Dr. Kurth’s excellent prospective evaluation of healthy women who had migraine with or without aura has uncovered a huge future risk of cardiovascular or cerebrovascular disease in that segment of women who have migraine with aura. We have... More


Migraine With Aura Is Linked With Increased Risk of Cardiovascular Disease in Women

AAN 2013 Meeting

Migraine With Aura Is Linked With Increased Risk of Cardiovascular Disease in Women

SAN DIEGO—Migraine with aura is a strong relative contributor to an increased risk of cardiovascular disease events in women, according to Tobias Kurth, MD, and colleagues.


Reporting at the 65th Annual... More


Are Low HDL and High LDL Cholesterol Linked to Cerebral Amyloidosis?

AAN 2013 Meeting

Are Low HDL and High LDL Cholesterol Linked to Cerebral Amyloidosis?

SAN DIEGO—A low level of HDL cholesterol and a high level of LDL cholesterol may be associated with elevated cerebral amyloid-beta in elderly persons with high vascular risk, according to a study presented at the 65th Annual... More


Solitaire FR May Be Safe and Effective for Recanalization

2013 International Stroke Conference

Solitaire FR May Be Safe and Effective for Recanalization

HONOLULU—The Solitaire FR device is associated with high rates of recanalization and good clinical outcomes in patients with acute ischemic stroke, researchers reported at the 2013 International Stroke Conference. According... More


DP-b99 Shows No Efficacy in Patients With Acute Ischemic Stroke

2013 International Stroke Conference

DP-b99 Shows No Efficacy in Patients With Acute Ischemic Stroke

HONOLULU—A phase III trial shows no evidence that DP-b99 provides benefits for patients with acute ischemic stroke when administered within nine hours of symptom onset, according to research presented at the 2013... More


Clinical History Helps Distinguish TIA and Stroke From Mimics

2013 International Stroke Conference

Clinical History Helps Distinguish TIA and Stroke From Mimics

HONOLULU—Clinical history is the key to distinguishing between transient ischemic attacks (TIAs) and strokes on one hand and their main mimics—including partial seizures and complicated migraine—on the other hand,... More


Medication Aids May Not Improve Adherence to Parkinson’s Disease Drugs

AAN 2013 Meeting

Medication Aids May Not Improve Adherence to Parkinson’s Disease Drugs

SAN DIEGO—The use of pillboxes and other medication management aids by patients with Parkinson’s disease may not be associated with increased medication adherence, according to research presented at the 65th Annual Meeting... More


PEGylated Interferon Beta-1a May Reduce Annualized Relapse Rate in Patients With MS

AAN 2013 Meeting

PEGylated Interferon Beta-1a May Reduce Annualized Relapse Rate in Patients With MS

SAN DIEGO—A drug formulation made of polyethylene glycol chains attached to interferon beta-1a (PEGylated interferon beta-1a) may reduce annualized relapse rate significantly for patients with relapsing-remitting multiple... More


IHS to Solicit Public Comment on Revised Headache Classification Criteria

HCNE 2013

IHS to Solicit Public Comment on Revised Headache Classification Criteria

STOWE, VERMONT—The third edition of the International Classification of Headache Disorders will soon be available on the website of the International Headache Society, Morris Levin, MD, reported at the 23rd Annual... More

New and Noteworthy Information—May 2013

News Roundup

New and Noteworthy Information—May 2013

Living in the stroke belt as an adolescent is significantly associated with a high risk of stroke, according to research published online ahead of print April 24 in Neurology. Researchers examined data for 24,544 stroke-free... More


Arterial Dilatation May Not Cause Migraine Pain

Literature Monitor

Arterial Dilatation May Not Cause Migraine Pain

Migraine pain may not be associated with extracranial arterial dilatation and may be linked with only slight intracranial dilatation, according to research published online ahead of print on April 9 in Lancet Neurology.

More


Duloxetine Reduces Chemo-Induced Neuropathy

Literature Monitor

Duloxetine Reduces Chemo-Induced Neuropathy

A five-week course of daily oral duloxetine reduced pain and improved function and quality of life for patients with chemotherapy-induced peripheral neuropathy, according to a study published in the April 3 issue of JAMA.

More


Dementia Costs Top Cancer, Heart Disease

Literature Monitor

Dementia Costs Top Cancer, Heart Disease

Dementia cost the United States economy between $159 billion and $215 billion in 2010, making it a greater financial burden than either cancer or heart disease, according to a study published in the April 4 New England ... More

 

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