Cover Article
Regular NSAID Use May Lower Risk for Parkinson's Disease
Adults who regularly take aspirin NSAIDs have a decreased risk of Parkinson's disease compared with controls, researchers reported in the November 6 Neurology.

Selected Articles

• Exploring the Pathogenesis of Rett Syndrome
• News Roundup: Late-Breaking Neurologic News
• Oral Fingolimod May Reduce the Damaging Effects of MS
• Topiramate May Be Effective for Treating Patients With Alcohol Dependence
• New Guidelines for First Unprovoked Seizure—And Other Recent Articles of Interest in Neurology

Cover Article
The Growing Global Burden of Neurologic Disease
Changing demographics in the world's most populous countries in the next few decades will result in a significant increase in the number of persons with neurodegenerative disease, according to Ray Dorsey, MD, MBA, at the 132nd Annual Meeting of the American Neurological Association.

Selected Articles

• Identifying Safe Drivers With Parkinson's Disease
• News Roundup: Late-Breaking Neurologic News
• Minocycline May Extend Stroke Treatment Window
• Natalizumab Withdrawal Poses Risk for New T2 Lesions in Patients With MS
• Identifying and Managing Autism Spectrum Disorders in Children—And Other Recent Articles of Interest in Neurology

Cover Article
The Cooling Effects of Therapeutic Hypothermia
A recent spinal cord injury to Buffalo Bills' football player Kevin Everett has heightened interest in the use of therapeutic hypothermia for the treatment of neurologic damage. However, a number of variables that need additional study, as well as logistical issues, currently stand in the way of the treatment's potential for wider application.

Selected Articles

• Migraine's Burden in the Workplace Is Significant
• News Roundup: Late-Breaking Neurologic News
• Ovary Removal Boosts Risks for Cognitive Impairment, Dementia, and Parkinsonism
• Screening Battery Assesses MS-Specific Cognitive Dysfunction
• Bacterial Meningitis Survivors May Be at Risk of Cognitive Impairment—And Other Recent Articles of Interest in Neurology

Cover Article
Medication Overuse Headache—Is Drug Withdrawal Alone An Effective Treatment?
Although physicians agree on the significance of medication overuse headache, there is no consensus on how to treta the condition. Some physicians beleive that drug withdrawal alone should be used as treatment, while others prefer a multifaceted approach. Proponents of each view made their case in a scientific debate at the 49th Annual Scientific Meeting of the American Headache Society.

Selected Articles

• Genetic Risk Factors for MS Identified
• News Roundup: Late-Breaking Neurologic News
• Minimally Conscious Patient Makes Strides Following Deep Brain Stimulation
• Off-Label Use of Alemtuzumab Yields Benefits and Risks in MS
• Warfarin May Be More Effective Than Aspirin in Elderly Stroke Patients with Atrial Fibrillation—And Other Recent Articles of Interest in Neurology

Cover Article
Gene Therapy is Safe and Effective for Parkinson's Disease
Results from the first in vivo gene therapy trial in Parkinson's disease indicate the procedure is safe and may provide a modest but significant symptomatic benefit. The study, which has been ongoing for more than three years, was published in the June 23 Lancet.

Selected Articles

• A New Severity-Based Classification of MS
• News Roundup: Late-Breaking Neurologic News
• Unified Score More Accurately Predicts Stroke After TIA
• "A Dead Body Climbed on Top of Me"— A Sign of Sleep Paralysis?
• Irreversible Disability Occurs at Younger Age in Childhood-Onset MS—And Other Recent Articles of Interest in Neurology

Cover Article
The Next Generation of MS Pharmacotherapy
New treatment approaches showed benefit in managing relapsing-remitting multiple sclerosis (RRMS) in clinical trials presented at the 59th Annual Meeting of the American Academy of Neurology.

Selected Articles

• A Potential New Weapon Against Alzheimer’s Disease
• News Roundup: Late-Breaking Neurologic News
• MRI Technique Detects Cognitive Impairment Before Symptoms Arise
• Riboflavin—A New Treatment Option for Essential Tremor?
• Atherosclerosis Is Associated With an Increased Risk of Dementia—And Other Recent Articles of Interest in Neurology

Cover Article
Progress in Treatment and Understanding of Muscle Diseases
From an FDA-approved treatment for Pompe’s disease to experimental therapeutics for muscular dystrophies to a unified theory of the mechanism of myotonic dystrophy, progress in muscle disease was the focus of a symposium at the 59th Annual Meeting of the American Academy of Neurology.

Selected Articles

• Do Stimulants in Energy Drinks Provoke Seizures?
• News Roundup: Late-Breaking Neurologic News
• Assessing the Effectiveness of Immunomodulatory Treatment in MS
• Personality Profile Predicts Chronicization of Migraine and Responsiveness to Treatment
• Testosterone Injections Improve Some Symptoms of MS—And Other Recent Articles of Interest in Neurology

Cover Article
Alzheimer's Disease: The Health Care Crisis of the 21st Century
Alzheimer's diseae has reached crisis proportions in the United States, with incidence, prevalence, and mortality all on the rise, according to the 2007 Alzheimer's Disease Facts and Figures report that was released in March by the Alzheimer's Assocation at the organization's annual public policy forum.

Selected Articles

• Is MS Therapy Underutilized?
• News Roundup: Late-Breaking Neurologic News
• A Commonsense Approach to Treating Migraine
• Stenting: Safer or Equal to Medical Therapy?
• Does Migraine With Aura Protect Against Memory Decline?—And Other Recent Articles of Interest in Neurology

Cover Article
A New Roadmap for Neuroprotection
Negative findings from the Stroke–Acute Ischemic NXY-059 Treatment (SAINT II) study, which was unable to replicate the positive findings from last year's SAINT I trial, have given researchers reason to reflect on the future course of a once-promising but as yet unfulfilled area of translational research.

Selected Articles

• Are White Matter Lesions a Plausible Risk Factor for Migraine?
• News Roundup: Late-Breaking Neurologic News
• Who Should Be Hospitalized Following a TIA?
• The Neglected Borderlands Between Stroke and Dementia
• Hemochromatosis Alleles Indicate Genetic Risk Factors for Stroke—And Other Recent Articles of Interest in Neurology

Cover Article
t-PA Use Safe in EDs Without Specialized Stroke Teams
Emergency physicians at community hospitals can use tissue plasminogen activator (t-PA) with reasonable safety, according to Phillip A. Scott, MD, and colleagues at the University of Michigan Health System.

Selected Articles

• "Benign" MS: Is Disability Just a Matter of Time?
• News Roundup: Late-Breaking Neurologic News
• RLS Patients Might Be at Risk for Pathologic Gambling
• Baby Boomers Impact Stroke Hospitalization Rates
• Serum Levels of LDL Cholesterol Are Found to Be Higher Among Many Stroke Patients—And Other Recent Articles of Interest in Neurology

Cover Article
High Folate Intake Might Reduce Risk of Alzheimer's Disease
High amounts of dietary and supplemental folate may correlate with a reduced risk of Alzheimer's disease, according to Josè A. Luchsinger, MD, an Assistant Professor of Medicine at Columbia University Medical Center, New York City, and colleagues.

Selected Articles

• Brain Abnormalities Common in Children With a First Seizure
• News Roundup: Late-Breaking Neurologic News
• Treating Seizures in the Emergency Department
• Profile for Dementia in Parkinson's Disease
• Depression Associated With Chronic and Severe Headaches in Women —And Other Recent Articles of Interest in Neurology

Cover Article
Can Vitamin D Prevent MS?
High circulating levels of vitamin D may reduce the risk for multiple sclerosis in Caucasians, according to a study published in the December 20 issue of JAMA.

Selected Articles

• Childhood Cancer Treatment Increases Stroke Risk
• News Roundup: Late-Breaking Neurologic News
• Cerebral Blood Volume Mapping May Predict Late-Onset Alzheimer’s Disease
• “Real World” Experiences With AED Therapy
• Decline In Stroke Incidence Outpaces Drop in Lifetime Risk —And Other Recent Articles of Interest in Neurology