Conference Coverage

What Will It Take to End Alzheimer’s Disease?


 

References

WASHINGTON, DC—What would it take to evaluate the range of suggested treatments to postpone, reduce, or completely prevent the clinical onset of Alzheimer’s disease as quickly as possible? How can neurologists find and support the approval of drugs that work within the next 10 years? To answer these questions, Eric Reiman, MD, Executive Director of the Banner Alzheimer’s Institute (BAI) in Phoenix, and his colleagues Pierre Tariot, MD, and Jessica Langbaum, PhD, developed the Alzheimer’s Prevention Initiative (API) with valuable input from numerous academic, industry, regulatory, and other stakeholders. Dr. Reiman described API’s efforts at the 2015 Alzheimer’s Association International Conference.

Genotyping Study
 Provides Blueprint for Research

There are many promising but unproven prevention therapies, Dr. Reiman noted. They include lifestyle and dietary changes; dietary supplements; and repurposeable medications, such as those currently used for cholesterol or hypertension, as well as a growing number of investigational disease-modifying agents. “A therapy that delays the clinical onset of Alzheimer’s disease by only five years without also increasing lifespan has the potential to reduce the number of afflicted individuals by half. The hope is that we can do even better than that.”

As these treatments may need to be started before the clinical onset of symptoms to be effective, the vast resources required to test them in clinical trials can be prohibitive. “It could take 50,000 healthy late middle-age volunteers and a 20-year trial to wait for enough individuals in the placebo group to develop dementia.”

For Dr. Reiman and his colleagues, a clue to solving this problem was suggested in 1993 by the results of a retrospective case–control study by Duke University researchers. In this study of families with a history of late-onset Alzheimer’s disease, subjects’ risk of the disease increased from 20% to as much as 90% with increasing number of apolipoprotein E type 4 (APOE4) alleles, and the age of onset decreased from 84 to 68. While prospective cohort studies continue to clarify the absolute risk with each genotype, studies have consistently confirmed the association between APOE4 gene dose and the risk of Alzheimer’s disease, Dr. Reiman pointed out.

The Birth of the API

Building on this research, Dr. Reiman and colleagues began a study to track the disease before symptom onset. “We wondered if we could use brain imaging and other biomarker methods in cognitively unimpaired individuals at different levels of genetic risk for Alzheimer’s disease,” he explained.

Dr. Reiman, Richard Caselli, MD, of Mayo Clinic Arizona, and their colleagues began a longitudinal study of cognitively unimpaired persons in late middle-age with two, one, or no copies of the APOE allele to detect and track the preclinical stages of Alzheimer’s disease. Over the years, they have detected and tracked the brain imaging changes associated with Alzheimer’s disease. Based on their findings, Dr. Reiman initially proposed the idea of using brain imaging end points in APOE4 carriers to evaluate repurposed medications and lifestyle interventions that might reduce the risk of Alzheimer’s disease in 24-month proof-of-concept prevention trials.

However, he and his BAI colleagues soon realized that brain imaging and other biomarker end points would be unlikely to support the regulatory approval of prevention therapies unless they could provide evidence to suggest that the biomarker end points had “theragnostic value,” meaning that a treatment’s effects on the relevant biomarker endpoints were a reasonable way to predict a clinical benefit. In other areas of medicine, there have been instances in which a treatment’s biomarker effects failed to predict a clinical benefit, causing regulatory agencies to have that additional evidence to support the approval of treatments based solely on “surrogate biomarker end points.”

From their research findings and this particular insight came the idea to start the API. “Our goal was to help accelerate the evaluation of prevention therapies,” Dr. Reiman said. “In 2009, we began to vet our ideas with numerous academic and industry researchers, NIH officials, and other stakeholder groups in public meetings. We proposed potentially license-enabling prevention trials of investigational anti-amyloid treatments in research participants, who, based on their genetic background and age, are at particularly high risk for the clinical onset of Alzheimer’s disease. We incorporated elements that could help establish the theragnostic value of biomarkers and help the entire field along the way, and we set out to develop public–private partnerships to help address our goals more effectively than we could on our own.”

API has relied on the complementary experience, expertise, and goals of its academic and industry partners, BAI’s overarching strategy for the rapid evaluation of prevention therapies, and promising anti-amyloid agents from its selected industry partners. It secured initial funding to support its first two prevention trials. It also secured commitments from its industry partners to share trial data and biological samples with the field after the trials are completed to help find faster ways to conduct prevention trials in the future. “To prevent Alzheimer’s disease, it will take a commitment from all of us,” Dr. Reiman emphasized.

Pages

Recommended Reading

Dietary Supplement May Improve Cognition
MDedge Neurology
Postop delirium heightens risk of other dangerous complications
MDedge Neurology
Smartphone app can pick up covert hepatic encephalopathy
MDedge Neurology
ESC: Atrial fibrillation accelerates brain atrophy
MDedge Neurology
EASD: High HbA1c linked to elevated dementia risk in patients with 2DM
MDedge Neurology
Prion-like transmission of neurodegenerative pathology stirs concern
MDedge Neurology
Aerobic Exercise Benefits Patients With Mild Cognitive Impairment
MDedge Neurology
Primary Care Screening Doubles 
Dementia Diagnosis Rate
MDedge Neurology
Excessive Television Viewing and Physical 
Inactivity Affect Midlife Cognitive Function
MDedge Neurology
Awareness of Memory Loss 
Declines Before Dementia Onset
MDedge Neurology

Related Articles